Pubblicazioni

AUTORI Antonio Moschetta, Angie L Bookout, David J Mangelsdorf PUBBLICATO DA Nature Medicine DATA PUBBLICAZIONE Dicembre 2004 DOI http://dx.doi.org/10.1038/nm1138 Abstract Cholesterol gallstone disease is characterized by several events, including cholesterol precipitation in bile, increased bile salt hydrophobicity and gallbladder inflammation. Here, we describe the same phenotype in mice lacking the bile acid receptor, FXR. Furthermore, in susceptible wild-type mice that.. Read more

AUTORI Giuseppe Lo Sasso,Stefania Murzilli, Lorena Salvatore, Ilenia D’Errico, Michele Petruzzelli, Paola Conca, Zhao-Yan Jiang, Laura Calabresi, Paolo Parini, Antonio Moschetta PUBBLICATO DA Cell Metabolism DATA PUBBLICAZIONE 04 Agosto 2010 DOI http://dx.doi.org/10.1016/j.cmet.2010.07.002 Abstract Several steps of the HDL-mediated reverse cholesterol transport (RCT) are transcriptionally regulated by the nuclear receptors LXRs in the macrophages, liver, and intestine. Systemic LXR activation via.. Read more

AUTORI Salvatore Modica, Francoise Gofflot, Stefania Murzilli, Andria D’Orazio, Lorena Salvatore, Fabio Pellegrini, Antonio Nicolucci, Giovanni Tognoni, Massimiliano Copetti, Rosa Valanzano, Serena Veschi, Renato Mariani-Costantini, Giuseppe Palasciano, Kristina Schoonjans, Johan Auwerx, Antonio Moschetta PUBBLICATO DA Gastroenterology DATA PUBBLICAZIONE Febbraio 2010 DOI http://dx.doi.org/10.1053/j.gastro.2009.09.060 Abstract BACKGROUND & AIMS: The WNT–adenomatous polyposis coli system controls cell fate in the intestinal epithelium, where compartment-specific.. Read more

AUTORI Giuseppe Lo Sasso, Nicola Celli, Mariaelena Caboni, Stefania Murzilli, Lorena Salvatore, Annalisa Morgano, Michele Vacca, Tommaso Pagliani, Paolo Parini, Antonio Moschetta PUBBLICATO DA Hepatology DATA PUBBLICAZIONE Aprile 2010 DOI http://dx.doi.org/10.1002/hep.23436 Abstract Cholesterol homeostasis is critical for cellular proliferation. Liver X receptor (LXR) alpha and beta are the nuclear receptors responsible for regulation of cholesterol metabolism. In physiological conditions, high.. Read more

AUTORI Chiara Degirolamo, Carlo Sabbà and Antonio Moschetta PUBBLICATO DA Nature Reviews Drug Discovery DATA PUBBLICAZIONE 16 November 2015 DOI https://doi.org/10.1038/nrd.2015.9 Abstract The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation during fasting. Given.. Read more

AUTORI Salvatore Modica, Michele Petruzzelli, Elena Bellafante, Stefania Murzilli, Lorena Salvatore, Nicola Celli, Giuseppe Di Tullio, Giuseppe Palasciano, Tarek Moustafa, Emina Halilbasic, Michael Trauner, Antonio Moschetta PUBBLICATO DA Gastroenterology DATA PUBBLICAZIONE Febbraio 2012 DOI http://dx.doi.org/10.1053/j.gastro.2011.10.028 Abstract Background & aims: Cholestasis is a liver disorder characterized by impaired bile flow, reduction of bile acids (BAs) in the intestine, and retention of.. Read more